• Med. Clin. North Am. · Jan 2016

    Review

    What Do We Know About the Pathophysiology of Chronic Pain? Implications for Treatment Considerations.

    • Gerald M Aronoff.
    • Carolina Pain Associates, PA, 1900 Randolph Road, Suite 1016, Charlotte, NC 28207, USA. Electronic address: painexpert@painexpert.com.
    • Med. Clin. North Am. 2016 Jan 1; 100 (1): 31-42.

    AbstractWe discuss the complex features of the pathophysiology of chronic pain and the implications for treatment and provide an overview of nociceptive processes, neuropathic pain, cold hyperalgesia, peripheral nerve injury, wind-up pain, central sensitization, and common clinical presentation and diagnostic criteria. Advanced medicine has proven that chronic pain need not involve any structural pathology as pain is a complex biopsychosocial experience. Treatment of the specific mechanisms responsible for pain should be aimed at preventing and or reducing dysfunctional neuro-plasticity resulting from poorly controlled chronic pain. Further study is needed to reduce the probability and of persistent changes that cause chronic pain.Copyright © 2016 Elsevier Inc. All rights reserved.

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