• Crit Care · Jun 2016

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    Surrogate endpoints and competing risk of death in cardiac arrest research.

    • Victoria A McCredie and Damon C Scales.
    • Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D108, Toronto, ON, M4N 3M5, Canada. victoria.mccredie@sunnybrook.ca.
    • Crit Care. 2016 Jun 29; 20 (1): 189.

    AbstractWe urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.

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