• P A Jones, I R Chambers, T Y M Lo, P J D Andrews, W Chaudhry, A Clark, J Croft, R Forsyth, B Fulton, A D Mendelow, G Wilson, and R A Minns.
• Child Life and Health, University of Edinburgh, Edinburgh, UK.
• Acta Neurochir. Suppl. 2005 Jan 1; 95: 29-32.

AbstractThis paper describes and validates a new Cumulative Pressure-Time Index (CPT) which takes into account both duration and degree of cerebral perfusion pressure (CPP) derangement and determines critical thresholds for CPP, in a paediatric head injury dataset. Sixty-six head-injured children, with invasive minute-to-minute intracranial pressure (ICP) and blood pressure monitoring, had their pre-set CPP derangement episodes (outside the normal range) identified in three childhood age-bands (2-6, 7-10, and 11-16 years) and global outcome assessed at six months post injury. The new cumulative pressure-time index more accurately predicted outcome than previously used summary measures and by varying the threshold CPP values, it was found that these physiological threshold values (< or = 48, < or = 52 and < or = 56 mmHg for 2-6, 7-10, and 11-16 years respectively) best predicted brain insult in terms of subsequent mortality and morbidity.

26 keywords...

hide…