• J. Appl. Physiol. · Dec 2001

    Randomized Controlled Trial Clinical Trial

    Integrated analysis of protein and glucose metabolism during surgery: effects of anesthesia.

    • T Schricker, R Lattermann, P Fiset, L Wykes, and F Carli.
    • Department of Anesthesia, Royal Victoria Hospital, McGill University, 687 Pine Ave. West, Montreal, Quebec, Canada H3A 1A1. thomas.schricker@mcgill.ca
    • J. Appl. Physiol. 2001 Dec 1; 91 (6): 2523-30.

    AbstractThe aim of this study was to assess dynamic changes in protein and glucose metabolism during surgery. Twelve patients undergoing colorectal surgery received either intravenous propofol anesthesia (n = 6) or inhalational anesthesia with desflurane (n = 6). Pre- and intraoperative protein and glucose kinetics were analyzed by an isotope dilution technique using L-[1-(13)C]leucine and [6,6-(2)H(2)]glucose. Plasma concentrations of glucose, lactate, free fatty acids, insulin, glucagon, and cortisol were measured before and after 2 h of surgery. The rates of appearance of leucine and glucose, leucine oxidation, protein synthesis, and glucose clearance decreased during surgery, independent of the type of anesthesia (P < 0.05). A correlation between the rate of appearance of leucine and glucose was observed (r = 0.755, P < 0.001). Intraoperative plasma cortisol and glucose concentrations increased (P < 0.05), whereas plasma concentrations of lactate, free fatty acids, insulin, and glucagon did not change. Surgery causes a depression of whole body protein and glucose metabolism, independent of the anesthetic technique. There is a correlation between perioperative glucose production and protein breakdown.

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