• Umberto Raucci, Caterina Tomasello, Marcello Marri, Marco Salzano, Augusto Gasparini, and Elena Conicella.
• Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
• Pain Pract. 2016 Sep 1; 16 (7): E103-9.

BackgroundComplex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation.AimWe evaluated Scrambler Therapy(®) (ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS.Materials And MethodsWe report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments.ResultsThe treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities.Discussion And ConclusionWe conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients.© 2016 World Institute of Pain.

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