• Eur. J. Pharmacol. · Feb 2014

    Review

    Pharmacological strategy for overcoming opioid-induced ventilatory disturbances.

    • Satoko Kimura and Akira Haji.
    • Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
    • Eur. J. Pharmacol. 2014 Feb 15; 725: 87-90.

    AbstractOpioids are among the most frequently used analgesics for treatment of severe pain. However, certain of their side-effects, particularly ventilatory disturbances, often restrict their use. Separation of analgesia from respiratory depression has long been a goal in the basic research and therapeutic use of opioids. This report briefly describes opioid-induced respiratory depression and possible pharmacological strategies to counteract this without affecting analgesia.© 2013 Elsevier B.V. All rights reserved.

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