• Minerva anestesiologica · Jun 2005

    Review

    Local anesthetics in pediatric anesthesia: an update.

    • C Ecoffey.
    • Department of Anesthesiology, Critical Care and Surgery, Pontchaillou Hospital, University of Rennes 1, Rennes, France.
    • Minerva Anestesiol. 2005 Jun 1; 71 (6): 357-60.

    AbstractFor several decades, bupivacaine has enjoyed great clinical popularity as the first choice local anesthetic in pediatrics. However, introduction of ropivacaine and levobupivacaine, the two newer and presumably safer (thought to be less cardio- and neurotoxic than bupivacaine) local anesthetics, has challenged the position of bupivacaine as a gold standard for prolonged duration of analgesia. This review article summarized the metabolism, the criteria of choice and the safety use of new agents.

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