• Aya Iizawa, Tsutomu Oshima, Yoshiko Kasuya, and Shuji Dohi.
• Department of Anesthesiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan.
• Can J Anaesth. 2004 Aug 1; 51 (7): 668-71.

PurposeTo compare oral tandospirone with oral clonidine in terms of preoperative anxiolysis.MethodsPreoperative anxiety was measured using the Spielberger state-trait anxiety inventory (STAI-state). Pretreatment evaluation was performed on the day before surgery and post-treatment examination immediately after entry into the operating room. In a double-blind, randomized design, three groups of 40 patients received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T group); 2) clonidine 3 microg.kg(-1) (C group); or 3) placebo (P group).ResultsFollowing premedication, the STAI-state decreased in the T group (P < 0.05) while exhibiting no significant changes in the C group. As far as the changes in the STAI-state were concerned, however, the P-group was different from each of the other groups (P < 0.05 vs T group and vs C group).ConclusionOral tandospirone was equivalent to oral clonidine in terms of reduction in preoperative anxiety.

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