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J. Psychopharmacol. (Oxford) · Jun 2003
Clinical TrialEffects of gabapentin on anxiety induced by simulated public speaking.
- Fernanda de-Paris, Marcia K Sant'Anna, Monica R M Vianna, Tatiana Barichello, Joao V Busnello, Flavio Kapczinski, Joao Quevedo, and Ivan Izquierdo.
- Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
- J. Psychopharmacol. (Oxford). 2003 Jun 1; 17 (2): 184-8.
AbstractThe effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.
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