• Oncology nursing forum · Apr 1994

    Review

    Cognitive dysfunction associated with biological response modifier therapy.

    • C M Bender.
    • Graduate Program, University of Pittsburgh, School of Nursing, PA.
    • Oncol Nurs Forum. 1994 Apr 1; 21 (3): 515-23; quiz 524-5.

    Purpose/ObjectivesTo review current knowledge regarding the cognitive dysfunction related to administration of biological response modifiers (BRMs), including assessment and nursing intervention.Data SourcesPublished studies of cognitive dysfunction in people receiving BRMs, including research based on clinical observation and using pre- and post-treatment measures of cognitive and neurologic function.Data SynthesisBRM-associated cognitive dysfunction is a significant clinical problem; however, its mechanisms of action are poorly understood. Clinical observation of patients cognitive and neurologic assessment, and interventions based on presence of premonitory symptomatology are warranted.ConclusionsContinued research into the causes of this problem and the definition of intervention protocols is needed.Implications For Nursing PracticeAnticipatory care including assessing for early identification and family involvement in monitoring for changes, performing structured assessment of cognitive function, ensuring patient safety and reorientation, if necessary, and minimizing sleep disturbances.

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