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Biomarkers in medicine · Jan 2014
Observational StudyAdrenomedullin is a useful biomarker for the prognosis of critically ill septic children.
- Iolanda Jordan, Patricia Corniero, Mònica Balaguer, Jessica Ortiz, David Vila, Jesús Velasco, Francisco J Cambra, and Elisabeth Esteban.
- Pediatric Intensive Care Unit Service, Hospital de Sant Joan de Déu, Barcelona, Spain.
- Biomark Med. 2014 Jan 1; 8 (9): 1065-72.
AimTo measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT).Materials & MethodsProspective observational study conducted on 95 patients.ResultsMean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively).ConclusionMR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.
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