• Stephan Hoch, James Fasunla, Behfar Eivazi, Jochen Alfred Werner, and Afshin Teymoortash.
• Department of Otolaryngology, Head and Neck Surgery, Philipp University, Marburg, Germany. hochs@med.uni-marburg.de
• Am J Otolaryngol. 2012 Sep 1; 33 (5): 505-9.

PurposePatients with surgically treated head and neck cancer and clinical N0 neck with high risk of occult lymph node metastasis undergo elective neck dissection (ND). Late lymph node metastasis may appear in those patients with pN0 neck. The aim of the present study was to analyze the incidence and clinical relevance of late lymph node metastasis in patients with head and neck cancer.Materials And MethodsThe clinical data of 61 patients with head and neck cancer who had undergone elective ND with pN0 neck were retrospectively analyzed. Only patients without local failure, second primary, or radiochemotherapy were included in the study.ResultsLate lymph node metastasis could be observed in 4 (6.5%) cases at the margin or outside the initially dissected lymph node levels. In those patients, the primary tumor was localized in the oral cavity (n = 3) or oropharynx (n = 1) and was classified in all cases as T1 or T2. Lymph node metastasis could be found in levels I (n = 2), II (n = 1), and IV (n = 1), respectively.ConclusionEven in the case of pN0 neck after an elective ND, the appearance of late lymph node metastases must be expected. The low proportion of patients with late lymph node metastases after a selective ND in clinical and histologic N0 does not justify an extended form of neck surgery.Copyright © 2012 Elsevier Inc. All rights reserved.

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