-
Review
Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy.
- Jörg Dietrich, Michelle Monje, Jeffrey Wefel, and Christina Meyers.
- Department of Neurology, Division of Neuro-Oncology, Stephen E and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jdietrich1@partners.org
- Oncologist. 2008 Dec 1; 13 (12): 1285-95.
AbstractStandard oncological therapies, such as chemotherapy and cranial radiotherapy, frequently result in a spectrum of neurocognitive deficits that includes impaired learning, memory, attention, and speed of information processing. In addition to classical mechanisms of neurotoxicity associated with chemo- and radiotherapy, such as radiation necrosis and leukoencephalopathy, damage to dynamic progenitor cell populations in the brain is emerging as an important etiologic factor. Radiation- and chemotherapy-induced damage to progenitor populations responsible for maintenance of white matter integrity and adult hippocampal neurogenesis is now believed to play a major role in the neurocognitive impairment many cancer survivors experience.
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