• Voen Med Zh · Mar 2015

    [An improvement of experimental model for a study of local hemostatic agents' effectiveness].

    • I M Samokhvalov, V A Reva, A V Denisov, K P Golovko, M V Sokhranov, S Yu Telitskii, and A B Yudin.
    • Voen Med Zh. 2015 Mar 1; 336 (3): 19-25.

    AbstractWith the help of tests on 10 big biological objects (sheep) was studied a modern model of severe lateral damage (6 mm diameter) of femoral artery. Within 45 seconds blood loss was 432.5 +/- 258.2 ml. The usage of domestic local hemostatic agent--"Gemostop" based on zeolite and "Gemofleks" based on chitosan. The total three-hour mortality was 50%. Primary hemostasis was recorded only in 20% of biological objects, the final hemostasis in 60%. Thus, the model of standard 6-mm lateral damage of femoral artery with a free primary hemmorage during 45 seconds should be considered as. optimal for evaluating the effectiveness of modern hemostatic agents.

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