• Br J Anaesth · Dec 2000

    Randomized Controlled Trial Clinical Trial

    Pre-operative oral erythromycin reduces residual gastric volume and acidity.

    • T Asai, K Murao, and K Shingu.
    • Department of Anesthesiology, Kansai Medical University, Moriguchi City, Osaka, Japan.
    • Br J Anaesth. 2000 Dec 1; 85 (6): 861-4.

    AbstractWe investigated whether low-dose erythromycin (200 mg) given as an oral premedicant altered the residual gastric volume and its acidity in fasted patients at induction of anaesthesia in a single-blinded study. Sixty patients were allocated randomly to receive either an erythromycin tablet (200 mg) or nothing with 10 ml water 3 h before induction of anaesthesia, and another 60 patients 1 h before induction of anaesthesia. Oral erythromycin significantly reduced residual gastric volume when it was given approximately 3 h (P<0.05; 95% CI for median difference: 0.1-17 ml) or 1 h (P<0.0005; 95% CI for median difference: 6-24 ml) before induction of anaesthesia. Erythromycin significantly reduced gastric acidity when it was given 1 h before induction of anaesthesia (P<0.02; 95% CI for median pH difference: 0.1-1.7). In contrast, when given 3 h before induction of anaesthesia, erythromycin did not significantly alter acidity.

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