• Hassan Soleimanpour, Saeid Safari, Farzad Rahmani, Asghar Jafari Rouhi, and Seyed Moayed Alavian.
• Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
• Anesth Pain Med. 2015 Feb 1; 5 (1): e23923.

ContextThe liver as an important organ in the body has many essential functions in physiological processes. One of the major activities of liver is drug metabolism. Hepatic dysfunction affecting hepatic physiological activities, especially drug metabolism can cause many problems during anesthesia and administration of different drugs to patients.Evidence AcquisitionStudies on hepatic disorders and hypnotic anesthetics prescribed in hepatic disorders were included in this review. For this purpose, reliable databases were used.ResultsAnesthesia should be performed with caution in patients with hepatic dysfunction and drugs with long half-life should be avoided in these patients.ConclusionsA review of the literature on the use of hypnotic drugs in patients with liver dysfunction showed that some hypnotic drugs used during anesthesia could be safely used in patients with impaired liver function. In these patients, certain drugs should be used with caution.

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