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- V González-Quintanilla, A Oterino, M Toriello, C de Pablos, Y Wu, E de Marco, and J Pascual.
- University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
- J Headache Pain. 2012 Jul 1; 13 (5): 425-9.
AbstractWe report the case of a patient diagnosed as having cluster-tic syndrome as the initial manifestation of multiple sclerosis (MS). The patient's headache bouts improved after treatment with antiepileptic drugs, steroids, and beta-interferon. Magnetic resonance imaging (MRI) scans showed a pontine demyelinating lesion involving the area of the trigeminal root inlet and main sensory nucleus. Neurophysiological studies correlated well with MRI lesions. The association between cluster-tic syndrome and MS is an exception, and the mechanism of the pain is still unknown; therefore, this case might suggest a pathophysiological relationship between the trigeminal main sensory nucleus and cluster-tic syndrome.
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