• Curr. Opin. Immunol. · Feb 2006

    Review

    Pentraxins as a key component of innate immunity.

    • Barbara Bottazzi, Cecilia Garlanda, Giovanni Salvatori, Pascale Jeannin, Angelo Manfredi, and Alberto Mantovani.
    • Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
    • Curr. Opin. Immunol. 2006 Feb 1; 18 (1): 10-5.

    AbstractPentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

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