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J. Matern. Fetal. Neonatal. Med. · Apr 2002
Randomized Controlled Trial Clinical TrialDoes nifedipine prevent the tachysystole associated with misoprostol induction?
- A Chao, Y Y El-Sayed, and A M V Sapugay.
- J. Matern. Fetal. Neonatal. Med. 2002 Apr 1; 11 (4): 266-9.
ObjectiveTo determine the efficacy of oral nifedipine as prophylaxis against uterine tachysystole associated with misoprostol induction of labor.MethodsA total of 116 patients undergoing induction with term, singleton pregnancies were enrolled. All patients received 50 microg misoprostol intravaginally every 4 h. Patients were randomly assigned also to receive nifedipine 10 mg orally every 4 h, or no prophylaxis. The primary outcome variable was the incidence of 12 or more contractions in any 20-min interval.ResultsData on 106 patients were available for analysis. There were 55 subjects in the misoprostol-nifedipine group and 51 controls. Nifedipine did not diminish the incidence of tachysystole when added to misoprostol (42% vs. 45% without nifedipine; p = 0.7).ConclusionProphylactic oral nifedipine was not shown to decrease the uterine tachysystole associated with vaginal misoprostol induction at a 50-microg dose.
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