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- Elsa Curtit, Laura Mansi, Erika Viel, Erion Dobi, Loïc Chaigneau, Thierry Nguyen, Xavier Pivot, Jean-Yves Blay, and Elsa Kalbacher.
- CHU Jean-Minjoz, 3, boulevard Fleming, 25030 Besançon Cedex, France. elsa.curtit7@wanadoo.fr
- Bull Cancer. 2012 Feb 1; 99 (2): 191-7.
AbstractScientific knowledge on gastrointestinal stromal tumors (GIST) has highly progressed over the last 10 years. The molecular bases of oncogenic transformation, KIT activating mutations, were identified in 1998 by Hirota et al. The product of KIT proto-oncogene, KIT protein, is a transmembrane receptor with tyrosine kinase activity. Tyrosine kinase inhibitors targeting these mutated activated kinases, namely imatinib and more recently sunitinib, nilotinib, masitinib or sorafenib, have deeply modified GIST prognosis. Molecular biology in GIST is now becoming a routine tool for treatment selection. In patients with advanced GIST, imatinib should be given until progression, and then, other tyrosine kinase inhibitors targeting KIT should be used. In the adjuvant setting, the optimal duration of imatinib treatment remains unknown.
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