• Robert J Schwartzman, Chamindra Gurusinghe, and Edward Gracely.
• Drexel University College of Medicine, Department of Neurology, Philadelphia, PA, USA.
• Pain Physician. 2008 Mar 1; 11 (2): 133-6.

BackgroundMore than 50% of multiple sclerosis patients experience chronic pain syndrome. We set out to determine the specific type of chronic pain that was seen in our multiple sclerosis patients.MethodsPatients with multiple sclerosis were catalogued between January 2002 and April 2006 and identified by a search of the database. Only MS patients that met the 2005 revised McDonald criteria were included.ResultsWe determined the prevalence rate of complex regional pain syndrome in a cohort of multiple sclerosis patients. In our sample of 205 multiple sclerosis patients, the prevalence of complex regional pain syndrome was 4 cases per 205 compared to an expected age and sex-adjusted total prevalence of 0.078 cases per 205 (p < 0.0001).ConclusionThis study suggests that multiple sclerosis patients are at a higher risk of developing complex regional pain syndrome than the general population.

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