• Luigi Biasco, Vincenzo Infantino, Fulvio Orzan, Silvia Vicentini, Chiara Rovera, Giada Longo, Alessandra Chinaglia, Riccardo Belli, Gianni Allais, and Fiorenzo Gaita.
• Division of Cardiology, Department of Medical Sciences, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Turin, Italy. Electronic address: luigi.biasco@gmail.com.
• J Cardiol. 2014 Nov 1; 64 (5): 390-4.

ObjectivesTo retrospectively evaluate the impact on daily activities of transcatheter closure of patent foramen ovale (PFO) versus medical therapy in patients with migraine and to analyze the role of the residual shunt after PFO closure.BackgroundWhile non-controlled observational studies reported an improvement of migraine after PFO closure, a randomized trial has shown no benefit of such an intervention. The role of residual shunt after PFO closure is also poorly known.MethodsOut of 217 patients with migraine and echocardiographic evidence of PFO, 89 were managed with percutaneous PFO closure (Group A) while 128 were medically treated (Group B). All MIDAS questionnaires were obtained at the first evaluation and repeated at least 6 months after the index evaluation or after the PFO closure. All the patients were also asked to give a subjective estimate of their migraine status. A postprocedural transcranial Doppler study was available in 70 patients in Group A.ResultsThe mean basal MIDAS score did not differ between the two groups (p = 0.859). After a mean follow-up (FU) of 1399 ± 982 days the MIDAS score decreased significantly in both groups (Group A baseline vs FU, p < 0.001; Group B baseline vs FU, p < 0.001), but no differences were observed between groups (p = 0.204). However a significantly higher number of Group A patients reported a perceived clinical benefit or the disappearance of migraine compared to Group B (p < 0.001). Patients with moderate or severe residual right to left shunt were no more likely to have an higher MIDAS score or to complain of migraine than those with mild or no shunt.ConclusionsAlthough the overall evolution of migraine is not significantly different, the abolition of migraine occurs in a larger proportion after PFO closure.Copyright © 2014. Published by Elsevier Ltd.

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