• Neuroreport · Sep 2002

    Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression.

    • Vijayakumar Mavanji and Subimal Datta.
    • Sleep Research Laboratory, Department of Psychiatry and Behavioral Neuroscience, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.
    • Neuroreport. 2002 Sep 16; 13 (13): 1603-6.

    AbstractThe present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes compared to control saline injections. Atropine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes without changing the REM sleep latency compared to control saline microinjection. These results show for the first time that the REM sleep disturbances observed in clomipramine-treatment induced depressed rats can be attenuated by increasing and decreasing the brain noradrenergic and cholinergic activities, respectively.

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