• Epileptic Disord · Sep 2013

    Case Reports

    Anorgasmia during pregabalin add-on therapy for partial seizures.

    • Rocco Salvatore Calabrò, Rosaria De Luca, Patrizia Pollicino, and Placido Bramanti.
    • IRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
    • Epileptic Disord. 2013 Sep 1; 15 (3): 358-61.

    AbstractAnorgasmia is the inability to reach orgasm during sexual intercourse, and, although it is believed that around 90% of anorgasmia problems are related to psychological issues, the use of serotoninergic drugs, including antidepressants and atypical antipsychotics, is a common cause of situational anorgasmia. Pregabalin is a new antiepileptic drug, structurally related to gabapentin, and commonly used as adjunctive therapy for partial epilepsy and treatment of neuropathic pain in adults. Herein, we describe three men with epilepsy, who experienced severe anorgasmia after pregabalin add-on treatment.

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