• Michiya Igase, Katsuhiko Kohara, Keiji Igase, Shiro Yamashita, Mutsuo Fujisawa, Ryosuke Katagi, and Tetsuro Miki.
• Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. migase@m.ehime-u.ac.jp
• J. Neurol. Sci. 2013 Feb 15; 325 (1-2): 137-41.

BackgroundCerebral microbleeds (CMBs) detected on T2*-weighted MRI gradient-echo have been associated with increased risk of cerebral infarction. We evaluated risk factors for these lesions in a cohort of first-time ischemic stroke patients.MethodsPresence of CMBs in consecutive first-time ischemic stroke patients was evaluated. The location of CMBs was classified by cerebral region as strictly lobar (lobar CMBs) and deep or infratentorial (deep CMBs). Logistic regression analysis was performed to determine the contribution of lipid profile to the presence of CMBs.ResultsOne hundred and sixteen patients with a mean age of 70±10years were recruited. CMBs were present in 74 patients. The deep CMBs group had significantly lower HDL-C levels than those without CMBs. In univariable analysis, advanced periventricular hyperintensity grade (PVH>2) and decreased HDL-C were significantly associated with the deep but not the lobar CMB group. On logistic regression analysis, HDL-C (beta=-0.06, p=0.002) and PVH grade >2 (beta=3.40, p=0.005) were independent determinants of deep CMBs.ConclusionsLow HDL-C may be a risk factor of deep CMBs, including advanced PVH status, in elderly patients with acute ischemic stroke. Management of HDL-C levels might be a therapeutic target for the prevention of recurrence of stroke.Copyright © 2012 Elsevier B.V. All rights reserved.

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