• Poor Zamany Nejat Kermany Mahtab M Anesthesiology Department, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fatemeh Roodneshin, Niloofar Ahmadi Dizgah, Ebrahim Gerami, and Esmail Riahi.
• Anesthesiology Department, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
• Paediatr Anaesth. 2016 Oct 1; 26 (10): 1018-25.

BackgroundA detrimental effect of commonly used anesthetics on the neurodevelopmental and behavioral parameters has long been shown in young animals subjected to early childhood anesthesia. Epidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. However, these results are still preliminary and inconclusive.AimTo further elucidate the probability of occurrence of such adverse outcomes, we evaluated cognitive performance of children who underwent general anesthesia early in their childhood.MethodOne hundred and fifteen children aged 5-16 years with established glaucoma were included in the study. Of these, 68 children had a history of at least one general anesthesia with sevoflurane before age 3. Phonemic and semantic verbal fluency, and forward and backward digit span tests were performed to evaluate cognitive function in the study subjects.ResultsThe two-way anova revealed that all these variables showed significant changes in various age groups, but they were comparable among subjects with no, single, or multiple childhood anesthesia.ConclusionIt can be concluded that brief periods of anesthesia with single anesthetic sevoflurane may be safe for children under age 3.© 2016 John Wiley & Sons Ltd.

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