• Cheng-Fu Wan, Yan Liu, Dao-Song Dong, Lin Zhao, Qi Xi, Xue Yu, Wen-Yao Cui, Qiu-Shi Wang, and Tao Song.
• The First Affiliated Hospital of China Medical University, China.
• Pain Physician. 2016 Jul 1; 19 (5): E721-8.

BackgroundPostherpetic neuralgia (PHN) is often refractory to existing treatments. Treatment of the dorsal root ganglion (DRG) using monopolar pulsed radiofrequency (PRF), which is a non- or minimally neurodestructive technique, is not efficacious in all patients.ObjectivesThis study aimed to determine the safety and clinical efficacy of bipolar high-voltage, long-duration PRF on the DRG in PHN patients.Study DesignSelf before-after controlled clinical trial.SettingDepartment of Pain Medicine, the First Affiliated Hospital of China Medical University.MethodsNinety patients diagnosed with PHN for > 3months were included. Bipolar high-voltage, long-duration PRF at 42°C for 900 seconds was applied after the induction of paresthesias covered the regions of hyperalgesic skin. The therapeutic effects were evaluated using a visual analog scale (VAS) and the 36-item Short Form health survey (SF-36) before treatment and one, 4, 8, and 12 weeks after PRF.ResultsThe VAS scores at one, 4, 8, and 12 weeks after PRF treatment were significantly lower than before treatment (P < 0.001). The SF-36 scores, which included physical functioning, physical role, bodily pain, general health perceptions, vitality, social function, emotional role, and the mental health index, were significantly improved up to 12 weeks after PRF treatment (P < 0.001). No serious adverse effects were identified following treatment. The main adverse reactions included pain, tachycardia, and high blood pressure (especially when the field strength was enhanced).LimitationsSingle center study, relatively small number of patients, lack of a control group.ConclusionBipolar high-voltage, long-duration PRF on the DRG is an effective and safe therapeutic alternative for PHN patients. This treatment could improve the quality of life of PHN patients.Clinical Trial RegistrationNO ChiCTR-OCS-14005461.

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