• Michael N Dretsch, Noah Silverberg, Andrew J Gardner, William J Panenka, Tanja Emmerich, Gogce Crynen, Ghania Ait-Ghezala, Helena Chaytow, Venkat Mathura, Fiona C Crawford, and Grant L Iverson.
• 1 United States Army Aeromedical Research Laboratory , Fort Rucker, Alabama.
• J. Neurotrauma. 2017 Feb 15; 34 (4): 869-875.

AbstractRisk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics (apolipoprotein E [APOE], brain-derived neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of one or more prior concussions, compared with 35.6% (154/432) of those with other BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study.

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