• Acta Chir Belg · Nov 2013

    The effects of tramadol infiltration on wound healing in rats.

    • D Ozkan, D Seker, J Ergil, A Yalcindag, U Han, Z Ginis, M Akinci, and N Delibas.
    • Anesthesiology Department, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. derya_z@yahoo.com
    • Acta Chir Belg. 2013 Nov 1; 113 (6): 434-8.

    PurposeInfiltration of a local anesthetic to provide postoperative analgesia is a frequently used method. However the infiltrated agents may have negative effects on wound healing. This study aimed to investigate the effects of tramadol, a weak opioid with a local anesthetic effect, on wound healing.MethodsWistar albino rats were used in the study. Tramadol and saline infiltration was randomly performed on the left and right backs of rats. Following a linear incision, the site was sutured. A follow-up was conducted after seven days, and the tissue samples from both locations were extracted for histopathological examinations (fibrotic index : no fibrosis 0, mild 1, moderate 2, severe 3) and hydroxyproline measurements.ResultsThe hydroxyproline level found in the tramadol group was 0.060 +/- 0.04 ng/mg.protein. In the control group the hydroxyproline level was 0.012 +/-0.01 ng/mg.protein (p = 0.01). The fibrotic index levels in the tramadol group were higher than the control group (p < 0.001).ConclusionIt was concluded that tramadol infiltration in a surgical incision site has no adverse effect on wound healing.

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