• Aldo Gonzalez-Beicos, Shree Venkat, Tanakorn Songrug, Julio Poveda, Monica Garcia-Buitrago, Prasoon Poozhikunnath Mohan, and Govindarajan Narayanan.
• Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL. Electronic address: a.gonzalez-beicos@med.miami.edu.
• Tech Vasc Interv Radiol. 2015 Sep 1; 18 (3): 176-82.

AbstractIrreversible electroporation (IRE) is a novel therapy that has shown to be a feasible and promising alternative to conventional ablative techniques when treating tumors near vital structures or blood vessels. The clinical efficacy of IRE has been evaluated using established imaging criteria. This study evaluates the histologic and imaging response of hepatic and pancreatic malignancies that were surgically resected after IRE. In total, 12 lesions ablated with IRE were included, including 3 pancreatic carcinomas, 5 primary tumors of the liver, and 4 metastatic tumors of the liver. The rate of complete response to IRE was 25% based on the histologic evaluation of the resected tumors. Although treatment-related vessel wall changes were noted in several cases in histologic findings, there was no evidence of vascular luminal narrowing or obliteration in any of the specimens. The imaging response to IRE before surgical resection usually resulted in underestimation of disease burden when compared with the histologic response seen on the resected specimens.Copyright © 2015 Elsevier Inc. All rights reserved.

44 keywords...

hide…