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Arterioscler. Thromb. Vasc. Biol. · Aug 2009
Historical ArticleThe tissue-type plasminogen activator story.
- D Collen and H R Lijnen.
- Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49 Box 911, B-3000 Leuven, Belgium. desire.collen@med.kuleuven.be
- Arterioscler. Thromb. Vasc. Biol. 2009 Aug 1; 29 (8): 1151-5.
AbstractMilestones in the development of tissue-type plasminogen activator (t-PA) as a fibrin-specific thrombolytic agent include: purification of human t-PA from the culture fluid of the Bowes melanoma cell line, elucidation of the molecular basis of fibrin-specific plasminogen activation, first experimental animal models of thrombosis, first patient (renal allograft) treated with melanoma t-PA, pilot studies in patients with acute myocardial infarction, cloning and expression of recombinant t-PA providing sufficient amounts for large scale clinical use, and demonstration of its therapeutic benefit in large multicenter clinical trials.
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