• Cagatay Ozdol, Fatih Alagoz, Ali Erdem Yildirim, Murat Korkmaz, Ergun Daglioglu, Pergin Atilla, Sevda Muftuoglu, and Ahmet Deniz Belen.
• Antalya Education and Research Hospital, Department of Neurosurgery, Antalya, Turkey.
• Turk Neurosurg. 2015 Jan 1; 25 (5): 707-11.

AimSpongostan™ is a sterile, water-insoluble, porcine gelatin absorbable sponge, which is widely used as a hemostatic material. The aim of this study is to test the anti-fibrotic capacity of Spongostan™, using a craniotomy model in an experimental rabbit model.Material And MethodsEighteen rabbits were divided into two groups: Each group consisted of 9 rabbits, duratomy plus Spongostan™ (group 1), and duratomy without Spongostan™ (group 2). Right parietal bone was removed via trephine and low speed drill and dura was opened. On the group 1 rabbits, an appropriate piece of Spongostan™ was meticulously placed under dural layer. On group 2 rabbits, same procedures were repeated without Spongostan™. Histological sections were taken from each group and evaluated for degree of fibrosis and collagen fibers.ResultsThere was marked increase in number of fibroblasts and collagen fibers in group 2 rabbits, however most of the rabbits in Spongostan™ group demonstrate scarce histopathological findings for fibrosis.ConclusionWe conclude that an appropriately placed subdural Spongostan™ over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical operations.

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