• Elke Kalbe, Sarah Petra Rehberg, Ines Heber, Martin Kronenbuerger, Jörg B Schulz, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Inga Liepelt-Scarfone, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker, Carola Oberschmidt, Karsten Witt, Nele Schmidt, Brit Mollenhauer, Claudia Trenkwalder, Annika Spottke, Sandra Roeske, Hans-Ulrich Wittchen, Oliver Riedel, and Richard Dodel.
• Medical Psychology, Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), University Hospital Cologne, Cologne, Germany.
• J. Neurol. Neurosurg. Psychiatr. 2016 Oct 1; 87 (10): 1099-105.

ObjectiveInconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.MethodsSociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.Results269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.ConclusionsThis study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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