• Psychiatry research · Sep 2015

    Meta Analysis

    A meta-analysis of the response of pathological hoarding to pharmacotherapy.

    • Vlasios Brakoulias, Guy D Eslick, and Vladan Starcevic.
    • Discipline of Psychiatry, The University of Sydney, Sydney Medical School - Nepean, Penrith, New South Wales, Australia. Electronic address: vlasios.brakoulias@sydney.edu.au.
    • Psychiatry Res. 2015 Sep 30; 229 (1-2): 272-6.

    AbstractThis meta-analysis aimed to identify all studies that have assessed treatment response for pathological hoarding treated with pharmacological agents. Seven studies were identified with a total of 92 participants. Most participants had a diagnosis of obsessive-compulsive disorder. Studies assessed response to serotonin-reuptake inhibitors (SRIs); venlafaxine; methylphenidate; and augmentation of SRIs with quetiapine, minocycline and naltrexone. More than half (ER=0.58, 95% CI=0.37-0.76) of the participants treated with pharmacotherapy responded. This study encourages us to consider the use of SRIs in patients with hoarding disorder. The study also encourages more studies of pharmacotherapy for pathological hoarding, noting that these studies should use validated outcome measures that specifically assess pathological hoarding and novel agents that target the unique neurobiological correlates of pathological hoarding.Crown Copyright © 2015. Published by Elsevier Ireland Ltd. All rights reserved.

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