• Michiyo Kimoto, Kohei Murao, Makiko Yamada, Masayuki Teraguchi, Atsushi Ohashi, Akiko Takeyasu, Shinichi Nakao, and Koh Shingu.
• Department of Anesthesiology, Kansai Medical University Hospital, Moriguchi.
• Masui. 2005 Mar 1; 54 (3): 295-7.

AbstractNeonates with 18-trisomy syndrome have various anomalies including cardiac and facial anomalies. Active treatments for them have not been recommended due to a low survival over one year which is less than 10%. However, the survival over one year in our institute between 1985 and 2003 is higher at 22%, and we had a patient with survival of over 5 years. We report a case of anesthetic management in a male 18-trisomy neonate who received a radical repair of umbilical hernia immediately after his birth. Tracheal intubation was difficult due to small airway and facial anomalies; cleft clip, cleft palate, and macrognathia. Conventional ventilation was ineffective for elimination of carbon dioxide and oxygenation due to pulmonary hypoplasia and intra- and extra-cardiac shunts. A high frequency ventilation improved elimination of carbon dioxide and oxygenation.

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