• Alexander Hammer, Anahi Steiner, Ghassan Kerry, Gholamreza Ranaie, Eduard Yakubov, David Lichtenstern, Ingrid Baer, Christian M Hammer, Stefan Kunze, and Hans-Herbert Steiner.
• Department of Neurosurgery, Paracelsus Medical University, Nuremberg, Bavaria, Germany. Electronic address: alexander.hammer@klinikum-nuernberg.de.
• World Neurosurg. 2017 Feb 1; 98: 780-789.

ObjectiveTo compare the treatment results of ruptured aneurysms treated endovascularly with aneurysms treated with microsurgical clipping.MethodsThis prospective multicenter study recorded and analyzed 661 cases of ruptured intracranial aneurysms with consecutive subarachnoid hemorrhage treated between 1997 and 2014 at 2 large medical centers. Endovascular treatment was performed in 271 cases, and microsurgical treatment was performed in 390 cases. The treatment modality was chosen by neuroradiologists and vascular neurosurgeons and was classified by predetermined decision criteria.ResultsSymptomatic ischemic stroke occurred in 46 patients (17.0%) in the endovascular group versus 26 patients (6.7%) in the microsurgery group (odds ratio [OR] = 2.86; 95% confidence interval [CI], 1.72-4.76; P < 0.0001). There was a significantly better occlusion rate (OR = 11.48; 95% CI, 5.10-25.83; P < 0.0001) in the microsurgery group compared with the endovascular group. The rebleeding rate was significantly lower in the microsurgery group (OR = 14.90; 95% CI, 1.90-117.13; P = 0.00085). No patient required retreatment in the microsurgery group, whereas 23 patients required retreatment in the endovascular group (P < 0.0001). There was no significant difference regarding the low direct mortality rate of coil embolization versus microsurgical clipping (P = 0.21).ConclusionsMicrosurgical clipping shows a lower rate of treatment-associated complications and a higher occlusion rate of ruptured intracranial aneurysms than coil embolization. The individual evaluation and decision process for choice of treatment modality in this study is very effective.Copyright © 2016 Elsevier Inc. All rights reserved.

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