• Neuroimaging Clin. N. Am. · Aug 2016

    Review

    Prenatal Cerebellar Disruptions: Neuroimaging Spectrum of Findings in Correlation with Likely Mechanisms and Etiologies of Injury.

    • Andrea Poretti, Eugen Boltshauser, and Thierry A G M Huisman.
    • Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Charlotte R. Bloomberg Children's Center, The Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD 21287-0842, USA; Department of Pediatric Neurology, University Children's Hospital, Steinwiesstrasse 75, Zurich 8032, Switzerland. Electronic address: aporett1@jhmi.edu.
    • Neuroimaging Clin. N. Am. 2016 Aug 1; 26 (3): 359-72.

    AbstractThere is increasing evidence that the cerebellum is susceptible to prenatal infections and hemorrhages and that congenital morphologic anomalies of the cerebellum may be caused by disruptive (acquired) causes. Starting from the neuroimaging pattern, this report describes a spectrum of prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. The neuroimaging findings, possible causative disruptive events, and clinical features of each disruption are discussed. Recognition of cerebellar disruptions and their differentiation from cerebellar malformations is important in terms of diagnosis, prognosis, and genetic counselling.Copyright © 2016 Elsevier Inc. All rights reserved.

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