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Comparative Study
Aerosol and subcutaneous measles vaccine: measles antibody responses 6 years after re-vaccination.
- Athmanundh Dilraj, Reshma Sukhoo, Felicity T Cutts, and John V Bennett.
- Unit for Clinical and Biomedical TB Research, Medical Research Council, 491 Ridge Road, Overport, Durban 4001, South Africa. dilraja@mrc.ac.za
- Vaccine. 2007 May 22; 25 (21): 4170-4.
AbstractThere are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much longer lasting antibody response than injected vaccine and should thus provide more durable protection against measles.
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