• Arch. Esp. Urol. · Nov 2009

    Review

    [Intermittent androgen deprivation (IAD) for advanced prostate cancer. Why not the standard of therapy?].

    • Dominique Prapotnich, Rafael Sánchez-Salas, Xavier Cathelineau, Oleksandr Stakhovskyi, José E A Rocha, and Guy Vallancien.
    • Urology Department, Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France. dominique.prapotnich@imm.fr
    • Arch. Esp. Urol. 2009 Nov 1; 62 (9): 689-94.

    Summary ObjectivesTo review the literature and present a contemporary image of androgen deprivation for prostate cancer.MethodsWe conducted a PubMed search on intermittent androgen deprivation. Articles obtained on intermittent androgen deprivation (IAD) and the experiences at Institut Montsouris were used for the review.ResultsIAD is an approach to hormonal deprivation that holds effective cancer control while preventing the morbidity associated with continuous androgen blockade. IAD nuances have been assessed by urological community teams in order to verify its possible potential benefits. Evidence based approach supports the idea of IAD as a standard of therapy for advanced prostate cancer requiring hormone deprivation. Variation among medical teams' criteria for the treatment and surveillance await standardization.ConclusionsReassessing the gold standard of hormonal blockade in advanced prostate cancer is mandatory.The undeniable evolution of IAD needs to be embraced by the urological community.

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