• Silvana F Bonilla, Alejandro Flores, Carl-Christian A Jackson, Walter J Chwals, and Bruce A Orkin.
• Division of Pediatric Gastroenterology, Floating Hospital for Children at Tufts Medical Center. Electronic address: sbonilla@tuftsmedicalcenter.org.
• J. Pediatr. Surg. 2013 Sep 1; 48 (9): 1931-5.

BackgroundAntegrade continence enema (ACE) is a recognized therapeutic option in the management of pediatric refractory constipation. Data on the long-term outcome of patients who fail to improve after an ACE-procedure are lacking.PurposeTo describe the rate of ACE bowel management failure in pediatric refractory constipation, and the management and long term outcome of these patients.MethodsRetrospective analysis of a cohort of patients that underwent ACE-procedure and had at least 3-year-follow-up. Detailed analysis of subsequent treatment and outcome of those patients with a poor functional outcome was performed.Results76 patients were included. 12 (16%) failed successful bowel management after ACE requiring additional intervention. Mean follow-up was 66.3 (range 35-95 months) after ACE-procedure. Colonic motility studies demonstrated colonic neuropathy in 7 patients (58%); abnormal motility in 4 patients (33%), and abnormal left-sided colonic motility in 1 patient (9%). All 12 patients were ultimately treated surgically. Nine patients (75%) had marked clinical improvement, whereas 3 patients (25%) continued to have poor function issues at long term follow-up.ConclusionsColonic resection, either segmental or total, led to improvement or resolution of symptoms in the majority of patients who failed cecostomy. However, this is a complex and heterogeneous group and some patients will have continued issues.Copyright © 2013 Elsevier Inc. All rights reserved.

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