• Y Mizuno, H Takada, K Urakami, K Ihara, R Kira, A Suminoe, S Ohga, T Aoki, and T Hara.
• Department of Pediatric Infectious Disease, Fukuoka Children's Hospital and Medical Center for Infectious Diseases, Japan. YR100265@niftyserve.or.jp
• J. Child Neurol. 2000 Jan 1; 15 (1): 19-21.

AbstractNeurotrophin-3 levels were measured in the cerebrospinal fluid of 35 patients with bacterial meningitis, viral meningitis, or encephalitis by two-site enzyme immunoassay. Elevated cerebrospinal fluid levels of neurotrophin-3 were demonstrated in 8 of 18 patients with bacterial meningitis. Follow-up examination of the eight patients at the convalescent stage showed diminished cerebrospinal fluid levels of neurotrophin-3. In contrast, none of the 17 patients with viral meningitis or encephalitis showed an elevation of neurotrophin-3 levels in cerebrospinal fluid. No relationships were observed between neurotrophin-3 levels and cerebrospinal fluid cell numbers, cerebrospinal fluid protein levels, serum C-reactive protein concentrations, or outcome in bacterial meningitis. Since neurotrophin-3 is involved in the survival of neurons and the modulation of the immune system, neurotrophin-3 could play a neuroprotective or immunomodulatory role in bacterial meningitis.

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