• Epileptic Disord · Mar 2005

    Case Reports

    Leucopenia and thrombocytopenia possibly associated with lamotrigine use in a patient.

    • Ali Ugur Ural, Ferit Avcu, Zeki Gokcil, Oral Nevruz, and Turker Cetin.
    • Department of Haematology, Medical and Cancer Research Center, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey. aural@gata.edu.tr
    • Epileptic Disord. 2005 Mar 1; 7 (1): 33-5.

    AbstractHaematological side effects are rather exceptional with lamotrigine. We report the case of a 25-year-old woman with epilepsy who developed combined leucopenia and thrombocytopenia eight weeks after starting lamotrigine. Within weeks after lamotrigine was discontinued, all of the haematopoietic abnormalities had disappeared. To our knowledge, this is the first report of combined leucopenia and thrombocytopenia associated with lamotrigine treatment suggesting, in our patient, a causal reaction.

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