• Neuroscience letters · Jun 2012

    Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons.

    • Jianguo Li, Naihong Liu, Ye Wang, Rui Wang, Dawei Guo, and Ce Zhang.
    • Department of Physiology, Shanxi Medical University, Taiyuan 030001, China. lijg71@gmail.com
    • Neurosci. Lett. 2012 Jun 19; 518 (2): 92-5.

    AbstractHippocampal CA1 pyramidal neurons are sensitive to ischemic damage. However, the cellular and molecular mechanisms underlying neuronal cell death caused by ischemia-reperfusion (I/R) are not completely clear. Here, we report that the ephrinA/EphA cell-cell interaction signaling pathway plays an important role in the apoptosis of hippocampal CA1 pyramidal neurons induced by I/R. We found that the expression of ephrinA3 and EphA4 is increased in the CA1 region following transient forebrain ischemia. Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation. These results reveal a novel function of ephrin/Eph signaling in the regulation of apoptosis in CA1 pyramidal neurons after I/R.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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