• Heart · Aug 2013

    Multicenter Study Comparative Study

    Assessment of valve haemodynamics, reverse ventricular remodelling and myocardial fibrosis following transcatheter aortic valve implantation compared to surgical aortic valve replacement: a cardiovascular magnetic resonance study.

    • Timothy A Fairbairn, Christopher D Steadman, Adam N Mather, Manish Motwani, Daniel J Blackman, Sven Plein, Gerry P McCann, and John P Greenwood.
    • Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS1 3EX, UK.
    • Heart. 2013 Aug 1; 99 (16): 1185-91.

    ObjectiveTo compare the effects of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) on aortic valve haemodynamics, ventricular reverse remodelling and myocardial fibrosis (MF) by cardiovascular magnetic resonance (CMR) imaging.DesignA 1.5 T CMR scan was performed preoperatively and 6 months postoperatively.SettingUniversity hospitals of Leeds and Leicester, UK.Patients50 (25 TAVI, 25 SAVR; age 77±8 years) high-risk severe symptomatic aortic stenosis (AS) patients.Main Outcome MeasuresValve haemodynamics, ventricular volumes, ejection fraction (EF), mass and MF.ResultsPatients were matched for gender and AS severity but not for age (80±6 vs 73±7 years, p=0.001) or EuroSCORE (22±14 vs. 7±3, p<0.001). Aortic valve mean pressure gradient decreased to a greater degree post-TAVI compared to SAVR (21±8 mm Hg vs. 35±13 mm Hg, p=0.017). Aortic regurgitation reduced by 8% in both groups, only reaching statistical significance for TAVI (p=0.003). TAVI and SAVR improved (p<0.05) left ventricular (LV) end-systolic volumes (46±18 ml/m2 vs. 41±17 ml/m2; 44±22 ml/m2 vs. 32±6 ml/m2 and mass (83±20 g/m2 vs. 65±15 g/m2; 74±11 g/m2 vs. 59±8 g/m2). SAVR reduced end-diastolic volumes (92±19 ml/m2 vs. 74±12 ml/m2, p<0.001) and TAVI increased EF (52±12% vs. 56±10%, p=0.01). MF reduced post-TAVI (10.9±6% vs. 8.5±5%, p=0.03) but not post-SAVR (4.2±2% vs. 4.1±2%, p=0.98). Myocardial scar (p≤0.01) and baseline ventricular volumes (p<0.001) were the major predictors of reverse remodelling.ConclusionsTAVI was comparable to SAVR at LV reverse remodelling and superior at reducing the valvular pressure gradient and MF. Future work should assess the prognostic importance of reverse remodelling and fibrosis post-TAVI to aid patient selection.

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