• J Neuropsychiatry Clin Neurosci · Jan 2009

    Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study.

    • Antonio Carlos Lopes, Benjamin D Greenberg, Georg Norén, Miguel Montes Canteras, Geraldo F Busatto, Maria Eugênia de Mathis, Anita Taub, Carina Chaubet D'Alcante, Marcelo Queiroz Hoexter, Fernando Sauerbronn Gouvea, Janaína Philippi Cecconi, André F Gentil, Ygor Arzeno Ferrão, Daniel Fuentes, Cláudio Campi de Castro, Cláudia C Leite, João Victor Salvajoli, Fábio L S Duran, Steven Rasmussen, and Eurípedes Constantino Miguel.
    • Obsessive Compulsive Spectrum Disorders Program (PROTOC), Department of Psychiatry, University of São Paulo School of Medicine, R. Dr. Ovídio Pires de Campos, 785, 3 degrees andar, sala 9, São Paulo, SP 01060-970, Brazil. antonioclopesmd@gmail.com
    • J Neuropsychiatry Clin Neurosci. 2009 Jan 1; 21 (4): 381-92.

    AbstractA subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.

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