• Mona Momeni, Alain Poncelet, Jean Rubay, Amine Matta, Laurent Veevaete, Thierry Detaille, Laurent Houtekie, Stéphan Clement de Clety, Emilien Derycke, Stéphane Moniotte, Thierry Sluysmans, and Francis Veyckemans.
• Department of Anesthesiology, Université Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium. Electronic address: mona.momeni@uclouvain.be.
• J. Cardiothorac. Vasc. Anesth. 2017 Feb 1; 31 (1): 122-127.

ObjectivesThis study evaluated the prognostic value of postoperative cardiac troponin-I (cTnI) in predicting all-cause mortality up to 3 months after normothermic congenital cardiac surgery.DesignProspective observational study.SettingUniversity hospital.ParticipantsAll children ages 0 to 10 years.InterventionsNone.Measurements And Main ResultscTnI was measured after the induction of anesthesia but before the surgery, at the pediatric intensive care unit arrival, and at 4, 12, and 24 hours postoperatively. Follow-up was extended up to 6 months. Overall, 169 children were analyzed, of whom 165 were survivors and 4 were nonsurvivors. cTnI levels were significantly higher in nonsurvivors only at 24 hours (p = 0.047). Children undergoing surgery with cardiopulmonary bypass (CPB) had significantly higher cTnI concentrations compared with those without CPB (p<0.001). Logistic regression analysis was performed on the 146 children in the CPB group with the following predictive variables: CPB time, postoperative cTnI concentrations, the presence of a cyanotic malformation, and intramyocardial incision. None of the variables predicted mortality. Postoperative cTnI concentrations did not predict 6 months׳ mortality. Only cTnI at 24 hours predicted the length of stay in the pediatric intensive care unit.ConclusionsThis study did not find that postoperative cTnI concentration predicted midterm mortality after normothermic congenital heart surgery. (ClinicalTrials.gov identifier: NCT01616394).Copyright © 2017 Elsevier Inc. All rights reserved.

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