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Antimicrob. Agents Chemother. · Jul 2009
Comparative StudyComparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.
- Pierre Vaudaux, Bénédicte Fleury, Asllan Gjinovci, Elzbieta Huggler, Manuela Tangomo-Bento, and Daniel P Lew.
- Service of Infectious Diseases, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, Geneva 14, Switzerland. Pierre.Vaudaux@hcuge.ch
- Antimicrob. Agents Chemother. 2009 Jul 1; 53 (7): 3150-2.
AbstractTwice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 microg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.
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