• Maja Surbatrović, Darko Mirković, Sonja S Radaković, Miodrag Jevtić, and Nikola S Filipović.
• Srp Ark Celok Lek. 2011 Mar 1; 139 (3-4): 179-84.

IntroductionMortality rate in trauma complicated with sepsis is exceeding 50%. Outcome is not determined only by infection or trauma, but also by the intensity of immuno-inflammatory response.ObjectiveThe aim of this study was to determine the influence of sepsis on the immuno-inflammatory response, in the group of 35 traumatized men, of which in 25 cases trauma was complicated with sepsis.MethodsCytokines were measured by ELISA test in plasma. Blood samples were drown on the first, third and fifth day after ICU admission.ResultsProinflammatory cytokine IL-8 was 230-fold higher in trauma + sepsis group (1148.48 vs. 5.05 pg/ml; p < 0.01), and antiinflammatory cytokine IL-ra was 4-fold higher (1138.3 vs. 310.05 pg/ml; p < 0.01), whereas IL-12 and IL-4 showed no significant difference between the groups.ConclusionWe concluded that sepsis, as a complication after trauma, drastically enhances immuno-inflammatory response to insult, as indicated by IL-8 and IL-ra, but not IL-12 and IL-4.

20 keywords...

hide…