• Control Clin Trials · Dec 1997

    Comparative Study

    Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis.

    • J M Pogue and S Yusuf.
    • Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
    • Control Clin Trials. 1997 Dec 1; 18 (6): 580-93; discussion 661-6.

    AbstractWe propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative meta-analysis.

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