• Bulent Turan, Zeynep Osar Siva, Derya Uluduz, Dildar Konukoglu, Feyza Erenler, Sabahattin Saip, Baki Goksan, and Aksel Siva.
• Neurology Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey. deryaulu@yahoo.com.
• J Headache Pain. 2014 Apr 24; 15 (1): 2323.

BackgroundComorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.MethodsParticipants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.ResultsThe data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.ConclusionsDepression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.

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